Protein-DNA interactions:
A greater challenge understanding molecular recognition is
to rationalize the fast and highly specific binding of proteins
to DNA (a four letter code polymer). Preliminary studies on
atomic models of this problem have led us to focus on the
the sequence-specific binding of ions and residues on DNA, and in the
possible role that ion-dynamics might have biasing the
diffusion of proteins in a one-dimensional search of its
binding site along the DNA chain.
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