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Carlos J. Camacho
Structural Bioinformatics Lab
Department of Computational Biology
University of Pittsburgh

Research Projects

Protein-protein interactions

Protein binding dynamics

Protein docking

Protein-DNA interactions

Homology modeling
CASP5 results

Genomics and molecular evolution

Thermodynamic & dynamics of protein folding


Genomics and molecular evolution:

Knowledge of the complete genomic sequences of organisms provides an invaluable starting point towards an understanding of the organization and evolution of genomes. This information provides the raw data that enables the study of genomes as an interrelated self-organized collective as opposed to a mere set of individual genes. In a recent study, we constructed a simple evolutionary model based on random gene duplications with increasing modifications that successfully recover the gene family distributions in 21 microbial complete genomes. Furthermore, our model is predictive, i.e. based only on the total number of genes in a genome we can estimate the distribution of gene families in the genome. [See Related Articles]

Publications | Curriculum Vitae | Group/Collaborators | Useful Links

Carlos J. Camacho
Associate Professor
Department of Computational Biology
Department of Molecular Genetics and Biochemistry
University of Pittsburgh
W1041 Biomedical Science Tower
200 Lothrop St.
Pittsburgh, PA 15261
Office: (412) 648-7776
Fax: (412) 648-3163

Genome Evolution, PRL 2001